PERIPHERAL BLOOD LYMPHOCYTE PHENOTYPE OF ZAP-70+ AND ZAP-70− PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKAEMIA
نویسندگان
چکیده
منابع مشابه
Peripheral blood lymphocyte phenotype of ZAP-70⁺ and ZAP-70⁻ patients with B-cell chronic lymphocytic leukaemia.
BACKGROUND Up to now, the immune status of chronic lymphocytic leukemia (CLL) patients in association with the expression of zeta-chain-associated protein kinase 70 (ZAP-70) in leukemic cells has not been evaluated. AIM The aim of this work was the study of the peripheral blood (PB) T-lymphocyte phenotypes in ZAP-70-positive (ZAP-70(+)) and ZAP-70-negative (ZAP-70(-)) untreated patients with ...
متن کاملZAP-70 expression and prognosis in chronic lymphocytic leukaemia.
BACKGROUND Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease; many patients never need treatment, whereas some have poor outcomes. New treatments, which can induce complete remissions, allow patients with poor outlook to be treated while they are still asymptomatic. Whether or not the IgVH gene is mutated is the best predictor of clinical outcome, but this assay is unsuited to the ...
متن کاملThe clinical significance of ZAP-70 and CD38 expression in B-cell chronic lymphocytic leukaemia.
BACKGROUND B-cell chronic lymphocytic leukaemia (B-CLL) is a disease with a highly variable clinical course; some patients never need treatment, while others require intensive treatment early after diagnosis. Recently, some new prognostic factors, such as IgVH mutational status, ZAP-70 and the expression of CD38 in leukaemic cells were introduced to identify attenuated versus progressive types ...
متن کاملZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia.
BACKGROUND AND OBJECTIVES ZAP-70 expression is a recognized prognostic marker in chronic lymphocytic leukemia (CLL). The aim of this study was to analyze whether the methylation status of the ZAP-70 gene is associated with expression of the ZAP-70 protein. DESIGN AND METHODS Patients with CLL (n=87), acute lymphoblastic leukemia (n=13), mantle cell leukemia (n=13) and splenic marginal zone ly...
متن کاملExpression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.
We examined isolated leukemia B cells of patients with chronic lymphocytic leukemia (CLL) for expression of zeta-associated protein 70 (ZAP-70). CLL B cells that have nonmutated immunoglobulin variable region genes (V genes) expressed levels of ZAP-70 protein that were comparable to those expressed by normal blood T cells. In contrast, CLL B cells that had mutated immunoglobulin variable V gene...
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ژورنال
عنوان ژورنال: Experimental Oncology
سال: 2015
ISSN: 2312-8852,1812-9269
DOI: 10.31768/2312-8852.2015.37(1):73-76